10. One bettor came away with all the dough when My Little Chloe sprung to the lead up the inside on the backstretch and came in at 72-1 in the third race at The Loop on Aug. 16. Cory Manning trained and drove the five-year-old mare to victory, creating a $146.60 payoff. View Chart

9. Perhaps destined to appear on this list, Longshot Panic likely had the hearts of his backers racing as he approached the line at Woodbine Mohawk Park in the opener on Aug. 2. The gelding sat the pocket for Travis Henry and gradually reeled in pacesetter Im A Papi Hanover in the stretch, getting up right on the wire for a 72-1 upset and a $147.90 return — his second win at greater than 50-1 this year. View Chart